AN ENDOSOMAL NAADP-SENSITIVE TWO-PORE CA2+ CHANNEL REGULATES ER-ENDOSOME MEMBRANE CONTACT SITES TO CONTROL GROWTH FACTOR SIGNALING

An Endosomal NAADP-Sensitive Two-Pore Ca2+ Channel Regulates ER-Endosome Membrane Contact Sites to Control Growth Factor Signaling

Membrane contact sites are regions of close apposition between organelles that facilitate information Tanning Serum transfer.Here, we reveal an essential role for Ca2+ derived from the endo-lysosomal system in maintaining contact between endosomes and the endoplasmic reticulum (ER).Antagonizing action of the Ca2+-mobilizing messenger NAADP, inhibit

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Analysis of community question‐answering issues via machine learning and deep learning: State‐of‐the‐art review

Abstract Over the last couple of decades, community question‐answering sites (CQAs) have been a topic of much academic interest.Scholars have often leveraged traditional machine learning (ML) and deep learning (DL) to explore the ever‐growing volume ORG SAUERKRAUT of content that CQAs engender.To clarify the current state of the CQA literature

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